Utilization patterns of MRSA NAAT withing regional health system
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Publication Date
2025
Keywords
oregon, oaa 2025
Disciplines
Medical Education | Pharmacy and Pharmaceutical Sciences
Abstract
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) nucleic acid amplification tests (NAATs) have shown excellent negative predictive value for clinical MRSA infection and have consistently been shown to reduce vancomycin use. However, in many infections the prevalence of MRSA is sufficiently low that the MRSA NAAT may not be diagnostically useful, creating the potential for overutilization. The purpose of this project is to identify MRSA NAAT usage patterns in the Oregon region of a national health system. This is a multi-center, retrospective analysis of patients aged 18 or older who received an IV vancomycin treatment course between May 30, 2021 and November 30, 2023 and had a MRSA NAAT collected within the Oregon region of this health-system. The first objective is to describe how MRSA NAATs are being used within the Oregon region of this health system; the primary outcome will be mean time to de-escalation. Demographics, medication, microbiology, laboratory, and hospitalization data will be extracted electronically. Descriptive statistics will be used to describe baseline characteristics of the study population. Student’s t-test will be used to analyze the mean time to vancomycin de-escalation if normally distributed, otherwise Wilcoxon rank-sum. Results and Conclusions will be shared when the project is complete. (IRB approved)
Specialty/Research Institute
Graduate Medical Education
Specialty/Research Institute
Pharmacy
