Title
Effects of Age and Sex of on Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis.
Document Type
Article
Publication Date
1-4-2019
Publication Title
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Keywords
Cholestatic Liver Disease; Mortality; Risk stratification; Stratified Medicine
Abstract
BACKGROUND & AIMS: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences in sex and/or age at the start of ursodeoxycholic acid (UDCA) treatment are associated with response to therapy, based on biochemical markers, or differences in transplant-free survival.
METHODS: We performed a longitudinal retrospective study of 4355 adults in the Global PBC Study cohort, collected from 17 centers across Europe and North America. Patients received a diagnosis of PBC from 1961 through 2014. We evaluated the effects of sex and age on response to UDCA treatment (based on GLOBE score) and transplant-free survival using logistic regression and Cox regression analyses, respectively.
RESULTS: Male patients were older at the start of treatment (58.3±12.1 years vs 54.3±11.6 years for women; P
CONCLUSION: In longitudinal analysis of 4355 adults in the Global PBC Study, we associated patient age, but not sex, with response to UDCA treatment and transplant-free survival. Younger age at time of PBC diagnosis is associated with increased risk of treatment failure, liver transplant, and death.
Clinical Institute
Digestive Health
Department
Hepatology
Recommended Citation
Cheung, Angela C; Lammers, Willem J; Murillo Perez, Carla F; van Buuren, Henk R; Gulamhusein, Aliya; Trivedi, Palak J; Lazaridis, Konstantinos N; Ponsioen, Cyriel Y; Floreani, Annarosa; Hirschfield, Gideon M; Corpechot, Christophe; Mayo, Marlyn J; Invernizzi, Pietro; Battezzati, Pier Maria; Parés, Albert; Nevens, Frederik; Thorburn, Douglas; Mason, Andrew L; Carbone, Marco; Kowdley, Kris V; Bruns, Tony; Dalekos, George N; Gatselis, Nikolaos K; Verhelst, Xavier; Lindor, Keith D; Lleo, Ana; Poupon, Raoul; Janssen, Harry L; and Hansen, Bettina E, "Effects of Age and Sex of on Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis." (2019). Articles, Abstracts, and Reports. 1105.
https://digitalcommons.providence.org/publications/1105
