Title

Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach

Authors

Dan-Dan Tian
Cathrine Leonowens
Emily J Cox, Providence Sacred Heart Medical CenterFollow
Vanessa González-Pérez
Kosea S Frederick
Yolanda V Scarlett
Michael B Fisher
Mary F Paine

Document Type

Article

Publication Date

7-1-2019

Publication Title

Drug metabolism and disposition: the biological fate of chemicals

Abstract

Midazolam is a widely used index substrate for assessing effects of xenobiotics on CYP3A activity. A previous study involving human hepatocytes showed the primary route of midazolam metabolism, 1'-hydroxylation, shifted to

Department

Pharmacy

Recommended Citation

Tian, Dan-Dan; Leonowens, Cathrine; Cox, Emily J; González-Pérez, Vanessa; Frederick, Kosea S; Scarlett, Yolanda V; Fisher, Michael B; and Paine, Mary F, "Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach" (2019). Articles, Abstracts, and Reports. 1627.
https://digitalcommons.providence.org/publications/1627