Future Research Goals in Immunotherapy.
Surgical oncology clinics of North America
Biomarkers; Cancer vaccines; Combination immunotherapy; Immunoprofiling; Seromics; T-cell agonists
In our opinion the most urgent needs to improve patient outcomes are: 1) a deeper ability to measure cancer immunobiology, and 2) increased availability of agents that, coupled with predictive biomarkers, will be used to tailor anti-cancer immunity. Tailoring effective immunotherapy will entail combinations of immunotherapeutics that augment priming of anti-cancer immunity, boost expansion of effector and memory cells of the T, B and NK lineage, amplify innate immunity and relieve checkpoint inhibition. Alternatives to inducing adaptive immunity to cancer include synthetic immunology that incorporate bi-specifics that target T cells to cancer or adoptive immunotherapy with gene-modified immune cells.
Earle A. Chiles Research Institute
Hulett, Tyler W; Fox, Bernard A; Messenheimer, David J; Marwitz, Sebastian; Moudgil, Tarsem; Afentoulis, Michael E; Wegman, Keith W; Ballesteros-Merino, Carmen; and Jensen, Shawn M., "Future Research Goals in Immunotherapy." (2019). Articles, Abstracts, and Reports. 1640.