Future Research Goals in Immunotherapy.

Publication Title

Surgical oncology clinics of North America

Document Type

Article

Publication Date

7-1-2019

Keywords

Biomarkers; Cancer vaccines; Combination immunotherapy; Immunoprofiling; Seromics; T-cell agonists

Abstract

In our opinion the most urgent needs to improve patient outcomes are: 1) a deeper ability to measure cancer immunobiology, and 2) increased availability of agents that, coupled with predictive biomarkers, will be used to tailor anti-cancer immunity. Tailoring effective immunotherapy will entail combinations of immunotherapeutics that augment priming of anti-cancer immunity, boost expansion of effector and memory cells of the T, B and NK lineage, amplify innate immunity and relieve checkpoint inhibition. Alternatives to inducing adaptive immunity to cancer include synthetic immunology that incorporate bi-specifics that target T cells to cancer or adoptive immunotherapy with gene-modified immune cells.

Specialty

Earle A. Chiles Research Institute

Specialty

Oncology

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