Preliminary validation of the Claudication Symptom Instrument (CSI).

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Vascular medicine (London, England)


Aged; Cognition; Comparative Effectiveness Research; Female; Humans; Intermittent Claudication; Interviews as Topic; Male; Middle Aged; Pain Measurement; Patient Reported Outcome Measures; Peripheral Arterial Disease; Predictive Value of Tests; Reproducibility of Results; Severity of Illness Index; Washington


This article describes the development of the Claudication Symptom Instrument (CSI) and its measurement properties for evaluating the symptom experience of patients diagnosed with intermittent claudication (IC). We conducted semi-structured qualitative interviews with IC patients for item development and cognitive interviews in which patient comprehension of items was tested. We evaluated measurement properties using data collected and analyzed in the context of an observational comparative effectiveness study of IC treatments. Items measuring five symptom important to patients were developed and cognitively tested: Pain, Numbness, Heaviness, Cramping, and Tingling. Item means (higher means worse) ranged from 1.1 (Tingling) to 2.3 (Pain) (range: 0 'none' to 4 'extreme'). Rasch analysis yielded support for an overall score (χ

Clinical Institute

Cardiovascular (Heart)