Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers.

Publication Title

Cancer Discov

Document Type

Article

Publication Date

8-1-2019

Abstract

Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes that recognize mutant proteins expressed by autologous tumors that may represent ideal targets for immunotherapy. Using high-throughput immunologic screening of mutant gene products identified via whole-exome sequencing, we identified neoantigen-reactive tumor-infiltrating lymphocytes (TIL) from 62 of 75 (83%) patients with common gastrointestinal cancers. In total, 124 neoantigen-reactive TIL populations were identified, and all but one of the neoantigenic determinants were unique. The results of

Clinical Institute

Cancer

Clinical Institute

Digestive Health

Specialty

Earle A. Chiles Research Institute

Specialty

Oncology

Specialty

Gastroenterology

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