Brain pathology of a patient 7years after autologous hematopoietic stem cell transplantation for multiple sclerosis.
Journal of the neurological sciences
Autografts; Brain; Fatal Outcome; Female; Hematopoietic Stem Cell Transplantation; Humans; Middle Aged; Multiple Sclerosis, Chronic Progressive; Treatment Outcome; White Matter
Aggressive immunosuppression followed by autologous hematopoietic stem cell transplantation (aHSCT) can be an effective treatment for severe multiple sclerosis (MS), but not all stages of disease may benefit equally. The case of a 49-year-old woman with advanced secondary-progressive MS whose clinical course was not improved by aHSCT and who seven years after transplantation succumbed to complications of severe MS disease-related disability is presented. Autopsy findings of ongoing neurodegeneration despite only rare infiltrating T-lymphocytes illustrate that late MS disease may not represent a suitable disease stage for aHSCT.
Neurosciences (Brain & Spine)
Wundes, Annette; Bowen, J D; Kraft, George H; Maravilla, Kenneth R; McLaughlin, Bernadette; von Geldern, Gloria; Georges, George; Nash, Richard A; and Lu, Jian-Qiang, "Brain pathology of a patient 7years after autologous hematopoietic stem cell transplantation for multiple sclerosis." (2017). Articles, Abstracts, and Reports. 2394.