Title

Src Kinase Is Biphosphorylated at Y416/Y527 and Activates the CUB-Domain Containing Protein 1/Protein Kinase C δ Pathway in a Subset of Triple-Negative Breast Cancers.

Authors

Luke J Nelson
Heather J Wright
Nguyen B Dinh
Kevin D Nguyen
Olga V Razorenova
F Scott Heinemann, Department of Pathology, Hoag Memorial Hospital Presbyterian, Newport Beach, CaliforniaFollow

Document Type

Article

Publication Date

12-13-2019

Publication Title

The American journal of pathology

Abstract

Targeted therapeutics are needed for triple-negative breast cancer (TNBC). In this study, we investigated the activation of Src family of cytoplasmic tyrosine kinases (SFKs) and two SFK substrates-CUB-domain containing protein 1 (CDCP1) and protein kinase C δ (PKCδ)-in 56 formalin-fixed, paraffin-embedded (FFPE) TNBCs. Expression of SFK phosphorylated at Y416 (SFK_pY416

Department

Pathology & Laboratory Medicine

Recommended Citation

Nelson, Luke J; Wright, Heather J; Dinh, Nguyen B; Nguyen, Kevin D; Razorenova, Olga V; and Heinemann, F Scott, "Src Kinase Is Biphosphorylated at Y416/Y527 and Activates the CUB-Domain Containing Protein 1/Protein Kinase C δ Pathway in a Subset of Triple-Negative Breast Cancers." (2019). Articles, Abstracts, and Reports. 2593.
https://digitalcommons.providence.org/publications/2593