Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: Results from the ATTRACT Multicenter Randomized Trial.

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Publication Title

Vascular medicine (London, England)


Administration, Intravenous; Adult; Catheterization, Peripheral; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; North America; Postthrombotic Syndrome; Predictive Value of Tests; Quality of Life; Risk Factors; Severity of Illness Index; Thrombolytic Therapy; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Duplex; Venous Thrombosis


Few studies have documented relationships between endovascular therapy, duplex ultrasonography (DUS), post-thrombotic syndrome (PTS), and quality of life (QOL). The Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) trial randomized 692 patients with acute proximal deep vein thrombosis (DVT) to receive anticoagulation or anticoagulation plus pharmacomechanical catheter-directed thrombolysis (PCDT). Compression DUS was obtained at baseline, 1 month and 12 months. Reflux DUS was obtained at 12 months in a subset of 126 patients. Clinical outcomes were collected over 24 months. At 1 month, patients who received PCDT had less residual thrombus compared to Control patients, evidenced by non-compressible common femoral vein (CFV) (21% vs 35%,

Clinical Institute

Cardiovascular (Heart)