Title

Immunotherapy for Head and Neck Cancer.

Authors

Felix Sim
Rom Leidner, Earle A. Chiles Research Institute, Providence Cancer InstituteFollow
Richard Bryan Bell, Earle A. Chiles Research Institute, Providence Cancer InstituteFollow

Document Type

Article

Publication Date

4-1-2019

Publication Title

Hematology/oncology clinics of North America

Keywords

Head and Neck Neoplasms; Humans; Immunotherapy; Neoplasm Metastasis; Neovascularization, Pathologic; Squamous Cell Carcinoma of Head and Neck; Tumor Microenvironment

Abstract

The immune system has a vital role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). Immune evasion of cancer cells leads to progression of HNSCC. An understanding of this mechanism provides the basis for improved therapies and outcomes for patients. Through the tumor's influence on the microenvironment, the immune system can be exploited to promote metastasis, angiogenesis, and growth. This article provides an overview of the interaction between immune infiltrating cells in the tumor microenvironment, and the immunologic principles related to HNSCC. Current immunotherapeutic strategies and emerging results from ongoing clinical trials are presented.

Clinical Institute

Cancer

Department

Earle A. Chiles Research Institute

Department

Oncology

Department

Otolaryngology

Recommended Citation

Sim, Felix; Leidner, Rom; and Bell, Richard Bryan, "Immunotherapy for Head and Neck Cancer." (2019). Articles, Abstracts, and Reports. 3151.
https://digitalcommons.providence.org/publications/3151