Granuloma-like lesion at subcutaneous immunoglobulin site in a common variable immunodeficiency patient.
Publication Title
Immunotherapy
Document Type
Article
Publication Date
10-1-2019
Keywords
Common Variable Immunodeficiency; Granuloma; Humans; Immunization, Passive; Immunoglobulins, Intravenous; Injections, Subcutaneous; Middle Aged
Abstract
Immunoglobulin therapy is the main stay in the treatment of primary antibody deficiencies. Granulomatous lesions are common complication in patients with common variable immunodeficiency (CVID). We present the first case of cutaneous granuloma-like lesion at site of subcutaneous immunoglobulin injections in a patient with CVID. These lesions resolve overtime following switching treatment to intravenous immunoglobulin. Unlike granulomas associated with CVID, granulomatous lesion in this patient did not require any specific therapy, and resolved over a period of 4 weeks following switching subcutaneous immunoglobulin to intravenous immunoglobulin.
Specialty/Research Institute
Pathology & Laboratory Medicine
