Abstract 13055: Ambulatory Pressure-Guided Heart Failure Management at an Advanced Heart Failure Program Shows Benefit Across Baseline Pressure Ranges

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Introduction: Heart failure (HF) management guided by pulmonary artery pressure (PAP) monitoring using the CardioMEMS™ system has been shown to reduce PAP and HF hospitalization (HFH). Our aim was to examine the relationship between medical management, PAP change, and clinical outcomes in a single cohort of CardioMEMS™ patients in our advanced HF program.

Methods: We conducted retrospective analyses of PAP data (Abbott) and chart review of hospitalizations and total medication adjustments for 32 patients implanted with CardioMEMS™ at a non-transplant center. PAP change from baseline was estimated using area under the curve methodology. Rates of HFH within 6 and 12 months pre- and post-implant were compared using the Anderson-Gill regression modeling for recurrent events and presented as hazard ratio (HR) [95% CI]. Changes in PAP vs intensity of medication adjustments over time were graphed according to baseline pressure groups.

Results: Median age was 66 years (range 40-88), 50% were female, and 37.5% had preserved ejection fraction. Six patients (19%) had baseline PAP <25 mmHg, 13 patients (41%) had baseline PAP 25-35 mmHg, and 13 patients (41%) had baseline PAP ≥35 mmHg. The average change in mean PAP was -3.9±1.3 mmHg at 6 months (n=27) and -5.7±2.1 mmHg at 12 months (n=18). Adjustments in loop diuretics (53.9%, 152 adjustments) were most common. After implant, the risk of HFH decreased by 81% in 6 months (HR = 0.19 [0.10-0.37]; p<0.001) and 72% in 12 months (HR = 0.28 [0.14-0.55]; p=0.002). Patients with high baseline PAP had a high number of medication adjustments in the first 3 months, which effectively reduced PAP in subsequent months (Figure 1). Conversely, patients with low baseline PAP had increased medication adjustments and rising PAP over time.

Conclusions: PAP-guided HF management reduced PAP and HFH across pressure ranges in a real-world setting. The intensity of medication adjustments needed differed by patients’ baseline PAP.

Clinical Institute

Cardiovascular (Heart)


Center for Cardiovascular Analytics, Research + Data Science (CARDS)