Effects of growth hormone receptor antagonism and somatostatin analog administration on quality of life in acromegaly.
acromegaly; pegvisomant; quality of life; somatostatin analog
OBJECTIVE: Acromegaly is associated with impaired quality of life (QoL). We investigated the effects of biochemical control of acromegaly by growth hormone receptor antagonism vs somatostatin analog therapy on QoL.
PATIENTS: 116 subjects: n = 55 receiving a somatostatin analog (SSA group); n = 29 receiving pegvisomant (PEG group); n = 32 active acromegaly on no medical therapy (ACTIVE group).
MEASUREMENTS: Acromegaly QoL Questionnaire (AcroQoL), Rand 36-Item Short Form Survey (SF-36) and Gastrointestinal QoL Index (GIQLI); fasting glucose, insulin and IGF-1 levels (LC/MS, Quest Diagnostics).
RESULTS: There were no group differences in mean age, BMI or sex [(whole cohort mean ± SD) age 52 ± 14 years, BMI 30 ± 6 kg/m
CONCLUSION: Our data support a comparable QoL in patients receiving pegvisomant vs somatostatin analogs, despite the fact that the vast majority receiving pegvisomant did not respond to or were not able to tolerate somatostatin analogs.
Neurosciences (Brain & Spine)
Dichtel, Laura E; Kimball, Allison; Yuen, Kevin C J; Woodmansee, Whitney; Haines, Melanie S; Guan, Qiu Xia; Swearingen, Brooke; Nachtigall, Lisa B; Tritos, Nicholas A; Sharpless, Julie L; Kaiser, Ursula B; Gerweck, Anu V; and Miller, Karen K, "Effects of growth hormone receptor antagonism and somatostatin analog administration on quality of life in acromegaly." (2020). Articles, Abstracts, and Reports. 3491.