Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women.
Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant women. Broad changes and a highly choreographed profile were revealed: 4,995 metabolic features (of 9,651 total), 460 annotated compounds (of 687 total), and 34 human metabolic pathways (of 48 total) were significantly changed during pregnancy. Using linear models, we built a metabolic clock with five metabolites that time gestational age in high accordance with ultrasound (R = 0.92). Furthermore, two to three metabolites can identify when labor occurs (time to delivery within two, four, and eight weeks, AUROC ≥ 0.85). Our study represents a weekly characterization of the human pregnancy metabolome, providing a high-resolution landscape for understanding pregnancy with potential clinical utilities.
Women & Children
Obstetrics & Gynecology
Earle A. Chiles Research Institute
Liang, Liang; Rasmussen, Marie-Louise Hee; Piening, Brian D.; Shen, Xiaotao; Chen, Songjie; Röst, Hannes; Snyder, John K; Tibshirani, Robert; Skotte, Line; Lee, Norman Cy; Contrepois, Kévin; Feenstra, Bjarke; Zackriah, Hanyah; Snyder, Michael; and Melbye, Mads, "Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women." (2020). Articles, Abstracts, and Reports. 3731.