Memory in repeat sports-related concussive injury and single-impact traumatic brain injury.
Brain injury : [BI]
Background: Repeat sports-related concussive/subconcussive injury (RC/SCI) is related to memory impairment. Objective & Methods: We sought to determine memory differences between persons with RC/SCI, moderate-to-severe single-impact traumatic brain injury (SI-TBI), and healthy controls. MRI scans from a subsample of participants with SI-TBI were used to identify the neuroanatomical correlates of observed memory process differences between the brain injury groups. Results: Both brain injury groups evidenced worse learning and recall in contrast to controls, although SI-TBI group had poorer memory than the RC/SCI group. Regarding memory process differences, in contrast to controls, the SI-TBI group evidenced difficulties with encoding, consolidation, and retrieval, while the RC/SCI group showed deficits in consolidation and retrieval. Delayed recall was predicted by encoding, with consolidation as a secondary predictor in the SI-TBI group. In the RC/SCI group, delayed recall was only predicted by consolidation. MRI data showed that the consolidation index we used mapped onto hippocampal atrophy. Conclusions: RC/SCI is primarily associated with consolidation deficits, which differs from SI-TBI. Given the role of the hippocampus in memory consolidation and the fact that hyperphosphorylated tau tends to accumulate in the medial temporal lobe in RC/SCI, consolidation deficits may be a cognitive marker of chronic traumatic encephalopathy in athletes.
Neurosciences (Brain & Spine)
Orthopedics & Sports Medicine
Wright, Matthew J; Monti, Martin M; Lutkenhoff, Evan S; Hardy, David J; Litvin, Pavel Y; Kelly, Daniel F; Guskiewicz, Kevin; Cantu, Robert C; Vespa, Paul M; Hovda, David A; Lopez, Walter D; Wang, Christina; Swerdloff, Ronald; and Fuster, Joaquín M, "Memory in repeat sports-related concussive injury and single-impact traumatic brain injury." (2020). Articles, Abstracts, and Reports. 3814.