Title
United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics.
Document Type
Article
Publication Date
8-26-2020
Publication Title
Chest
Keywords
cards; cards publication
Abstract
BACKGROUND: The treatment, genotyping, and phenotyping of patients with World Health Organization Group 1 pulmonary arterial hypertension (PAH) have evolved dramatically in the last decade.
RESEARCH QUESTION: The United States Pulmonary Hypertension Scientific Registry was established as the first US PAH patient registry to investigate genetic information, reproductive histories, and environmental exposure data in a contemporary patient population.
STUDY DESIGN AND METHODS: Investigators at 15 US centers enrolled consecutively screened adults diagnosed with Group 1 PAH who had enrolled in the National Biological Sample and Data Repository for PAH (PAH Biobank) within 5 years of a cardiac catheterization matching qualifying hemodynamic criteria. Exposure and reproductive histories were collected by using a structured interview and questionnaire. The biobank provided genetic data.
RESULTS: Between 2015 and 2018, a total of 499 of 979 eligible patients with clinical diagnoses of idiopathic PAH (IPAH) or familial PAH (n = 240 [48%]), associated PAH (APAH; n = 256 [51%]), or pulmonary venoocclusive disease/pulmonary capillary hemangiomatosis (n = 3 [1%]) enrolled. The mean age was 55.8 years, average BMI was 29.2 kg/m
INTERPRETATION: Patients with Group 1 PAH remain predominately middle-aged women diagnosed with IPAH or APAH. Delays in diagnosis of PAH persist. Treatment with combinations of PAH-targeted medications is more common than in the past. Women often report pregnancy complications, as well as exposure to anorexigens, oral contraceptives, and/or recreational drugs. Results of genetic tests frequently identify unsuspected heritable PAH.
Clinical Institute
Cardiovascular (Heart)
Department
Cardiology
Department
Center for Cardiovascular Analytics, Research + Data Science (CARDS)
Recommended Citation
Badlam, Jessica B; Badesch, David B; Austin, Eric D; Benza, Raymond L; Chung, Wendy K; Farber, Harrison W; Feldkircher, Kathy; Frost, Adaani E; Poms, Abby D; Lutz, Katie A; Pauciulo, Michael W; Yu, Chang; Nichols, William C; Elliott, C Gregory; additional authors; and Airhart, Sophia, "United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics." (2020). Articles, Abstracts, and Reports. 3916.
https://digitalcommons.providence.org/publications/3916
