Atezolizumab Plus Chemotherapy for First-Line Treatment of Non-Squamous Non-Small Cell Lung Cancer: Results From the Randomized Phase III IMpower132 Trial.

Document Type


Publication Date


Publication Title

J Thorac Oncol


Lung cancer; atezolizumab; non-small cell; non-squamous


INTRODUCTION: We report final results from the Phase III IMpower132 study evaluating atezolizumab plus carboplatin or cisplatin and pemetrexed (APP) in patients with non-squamous non-small cell lung cancer (NSCLC).

METHODS: Chemotherapy-naive patients with stage IV non-squamous NSCLC without sensitizing EGFR or ALK genetic alterations were randomized 1:1 to receive 4 or 6 cycles of carboplatin or cisplatin plus pemetrexed (PP) or APP every 3 weeks, followed by maintenance therapy with atezolizumab plus pemetrexed or pemetrexed alone. Co-primary endpoints were overall survival (OS) and investigator-assessed progression-free survival (PFS).

RESULTS: The intention-to-treat population included 578 patients (APP, n=292; PP, n=286). At the primary PFS analysis (May 22, 2018; median follow-up, 14.8 months), APP demonstrated significant PFS improvement vs PP (median, 7.6 vs 5.2 months; stratified HR, 0.60 [95% CI: 0.49, 0.72]; P

CONCLUSIONS: IMpower132 met its co-primary PFS endpoint but not its co-primary OS endpoint, with numerical improvement for OS in the APP arm. APP had a manageable safety profile, with no new or unexpected safety signals identified.

Clinical Institute





Earle A. Chiles Research Institute