Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity.
Journal of neuroinflammation [electronic resource]
texas; lubbock; covenant
BACKGROUND: Emergent large vessel occlusion (ELVO) strokes are devastating ischemic vascular events for which novel treatment options are needed. Using vascular cell adhesion molecule 1 (VCAM1) as a prototype, the objective of this study was to identify proteomic biomarkers and network signaling functions that are potential therapeutic targets for adjuvant treatment for mechanical thrombectomy.
METHODS: The blood and clot thrombectomy and collaboration (BACTRAC) study is a continually enrolling tissue bank and registry from stroke patients undergoing mechanical thrombectomy. Plasma proteins from intracranial (distal to clot) and systemic arterial blood (carotid) were analyzed by Olink Proteomics for N=42 subjects. Statistical analysis of plasma proteomics used independent sample t tests, correlations, linear regression, and robust regression models to determine network signaling and predictors of clinical outcomes. Data and network analyses were performed using IBM SPSS Statistics, SAS v 9.4, and STRING V11.
RESULTS: Increased systemic (p
CONCLUSIONS: The current study provides novel data on systemic and intracranial VCAM1 in relation to stroke comorbidities, stroke severity, functional outcomes, and the role VCAM1 plays in complex protein-protein signaling pathways. These data will allow future studies to develop predictive biomarkers and proteomic targets for drug development to improve our ability to treat a devastating pathology.
Neurosciences (Brain & Spine)
Maglinger, Benton; Sands, Madison; Frank, Jacqueline A; McLouth, Christopher J; Trout, Amanda L; Roberts, Jill M; Grupke, Stephen; Turchan-Cholewo, Jadwiga; Stowe, Ann M; Fraser, Justin F; and Pennypacker, Keith R, "Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity." (2021). Articles, Abstracts, and Reports. 4967.