Supportive Management of Patients with Advanced Pheochromocytomas and Paragangliomas Receiving PRRT.

Publication Title

Curr Oncol

Document Type

Article

Publication Date

7-26-2021

Keywords

oregon; portland; ppmc; chiles

Abstract

Peptide receptor radionuclide therapy (PRRT) is used to treat patients with advanced malignant pheochromocytomas (PCCs) and paragangliomas (PGLs). Patients are at risk of a PRRT-induced catecholamine crisis, and standard guidelines regarding the prevention and management of infusion reactions are lacking. In this case series, the institutional experience of five sequential patients with metastatic PCCs and PGLs receiving PRRT on an outpatient basis is described, of which four had symptomatic tumors and three had a high burden of disease. All patients with symptomatic tumors were treated with preventive management prior to the initiation of PRRT, and no infusion reactions or catecholamine crises were documented. PRRT may be delivered safely on an outpatient basis for patients with metastatic PCCs and PGLs with the involvement of an interdisciplinary team.

Clinical Institute

Cancer

Specialty

Earle A. Chiles Research Institute

Specialty

Oncology

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