Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia.
Journal of the American College of Cardiology
cards; cards publication; oregon; portland; Acute Coronary Syndrome; Adult; Aged; Algorithms; Contrast Media; Coronary Angiography; Dose-Response Relationship, Drug; Echocardiography; Female; Healthy Volunteers; Humans; Infusions, Intravenous; Kinetics; Male; Microbubbles; Microcirculation; Middle Aged; Molecular Imaging; Myocardial Infarction; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardium; Percutaneous Coronary Intervention; Point-of-Care Systems; Young Adult
BACKGROUND: Noninvasive molecular imaging of recent ischemia can potentially be used to diagnose acute coronary syndrome (ACS) with high accuracy.
OBJECTIVES: The authors hypothesized that bedside myocardial contrast echocardiography (MCE) ischemic memory imaging could be achieved with phosphatidylserine microbubbles (MB
METHODS: A dose-finding study was performed in healthy volunteers (n = 17) to establish optimal MB
RESULTS: Based on dose-finding studies, 0.10 or 0.15 mL of MB
CONCLUSIONS: Molecular imaging with point-of-care echocardiography and MB
Center for Cardiovascular Analytics, Research + Data Science (CARDS)
Davidson, Brian P; Hodovan, James; Layoun, Michael; Golwala, Harsh; Zahr, Firas; and Lindner, Jonathan R, "Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia." (2021). Articles, Abstracts, and Reports. 5664.