Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia.

Brian P Davidson
James Hodovan
Michael Layoun, Providence St. Joseph Health - CARDS
Harsh Golwala
Firas Zahr
Jonathan R Lindner


BACKGROUND: Noninvasive molecular imaging of recent ischemia can potentially be used to diagnose acute coronary syndrome (ACS) with high accuracy.

OBJECTIVES: The authors hypothesized that bedside myocardial contrast echocardiography (MCE) ischemic memory imaging could be achieved with phosphatidylserine microbubbles (MB

METHODS: A dose-finding study was performed in healthy volunteers (n = 17) to establish optimal MB

RESULTS: Based on dose-finding studies, 0.10 or 0.15 mL of MB

CONCLUSIONS: Molecular imaging with point-of-care echocardiography and MB