Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach.
Drug metabolism and disposition: the biological fate of chemicals
Biological Products/pharmacokinetics; Drug Interactions/physiology; Humans; Pharmaceutical Preparations/metabolism
Pharmacokinetic interactions between natural products (NPs) and conventional medications (prescription and nonprescription) are a longstanding but understudied problem in contemporary pharmacotherapy. Consequently, there are no established methods for selecting and prioritizing commercially available NPs to evaluate as precipitants of NP-drug interactions (NPDIs). As such, NPDI discovery remains largely a retrospective, bedside-to-bench process. This Recommended Approach, developed by the Center of Excellence for Natural Product Drug Interaction Research (NaPDI Center), describes a systematic method for selecting NPs to evaluate as precipitants of potential clinically significant pharmacokinetic NPDIs. Guided information-gathering tools were used to score, rank, and triage NPs from an initial list of 47 candidates. Triaging was based on the presence and/or absence of an NPDI identified in a clinical study (≥20% or
Johnson, Emily J; González-Peréz, Vanessa; Tian, Dan-Dan; Lin, Yvonne S; Unadkat, Jashvant D; Rettie, Allan E; Shen, Danny D; McCune, Jeannine S; and Paine, Mary F, "Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach." (2018). Articles, Abstracts, and Reports. 574.