Title

Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.

Authors

William van der Touw
Kyeongah Kang
Yi Luan
Ge Ma
Sunny Mai
Lihui Qin
Guanglin Bian
Ruihua Zhang
Sathish Kumar Mungamuri
Hong-Ming Hu, Laboratory of Cancer Immunobiology, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213.Follow
Cheng Cheng Zhang
Stuart A Aaronson
Marc Feldmann
Wen-Chin Yang
Shu-Hsia Chen
Ping-Ying Pan

Document Type

Article

Publication Date

9-15-2018

Publication Title

Journal of immunology (Baltimore, Md. : 1950)

Abstract

Glatiramer acetate (GA; Copaxone) is a copolymer therapeutic that is approved by the Food and Drug Administration for the relapsing-remitting form of multiple sclerosis. Despite an unclear mechanism of action, studies have shown that GA promotes protective Th2 immunity and stimulates release of cytokines that suppress autoimmunity. In this study, we demonstrate that GA interacts with murine paired Ig-like receptor B (PIR-B) on myeloid-derived suppressor cells and suppresses the STAT1/NF-κB pathways while promoting IL-10/TGF-β cytokine release. In inflammatory bowel disease models, GA enhanced myeloid-derived suppressor cell-dependent CD4

Clinical Institute

Cancer

Department

Oncology

Department

Earle A. Chiles Research Institute

Recommended Citation

van der Touw, William; Kang, Kyeongah; Luan, Yi; Ma, Ge; Mai, Sunny; Qin, Lihui; Bian, Guanglin; Zhang, Ruihua; Mungamuri, Sathish Kumar; Hu, Hong-Ming; Zhang, Cheng Cheng; Aaronson, Stuart A; Feldmann, Marc; Yang, Wen-Chin; Chen, Shu-Hsia; and Pan, Ping-Ying, "Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B." (2018). Articles, Abstracts, and Reports. 665.
https://digitalcommons.providence.org/publications/665