Title

Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy.

Authors

Di Wen, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, Portland, Oregon, 97213, USA.
Tingxizi Liang
Guojun Chen
Hongjun Li
Zejun Wang
Jinqiang Wang
Ruxing Fu
Xiao Han
Tianyuan Ci
Yuqi Zhang
Peter Abdou
Ruoxin Li
Linlin Bu
Gianpietro Dotti
Zhen Gu

Document Type

Article

Publication Date

12-16-2022

Publication Title

Adv Sci (Weinh)

Keywords

oregon; eacri; chiles

Abstract

Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8+ T cell-mediated immune responses within the tumor microenvironment and favored dendritic cell maturation in the tumor draining lymph nodes.

Clinical Institute

Cancer

Department

Oncology

Department

Earle A. Chiles Research Institute

Recommended Citation

Wen, Di; Liang, Tingxizi; Chen, Guojun; Li, Hongjun; Wang, Zejun; Wang, Jinqiang; Fu, Ruxing; Han, Xiao; Ci, Tianyuan; Zhang, Yuqi; Abdou, Peter; Li, Ruoxin; Bu, Linlin; Dotti, Gianpietro; and Gu, Zhen, "Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy." (2022). Articles, Abstracts, and Reports. 6820.
https://digitalcommons.providence.org/publications/6820