A Rare Case of Demodicosis Following Treatment With Oral Fluconazole.

Publication Title

Cureus

Document Type

Article

Publication Date

1-1-2023

Keywords

oregon; chiles; antifungal; blepharitis; demodex; demodicosis; fluconazole; fungal microbiome; ivermectin; permethrin

Abstract

Demodex folliculorum and Demodex brevis are commensal human ectoparasites that reside within or near hair follicles and have been highly associated with rosacea-like papulopustular skin eruptions. We present an interesting case of recurrent, iatrogenic demodicosis in a 56-year-old man. We suspect this to have been triggered by antifungal therapy given it occurred twice closely following azole treatment. We propose that oral antifungals in the setting of immunosuppression can alter the skin microbiome, facilitating Demodex proliferation.

Clinical Institute

Cancer

Specialty

Dermatology

Specialty

Earle A. Chiles Research Institute

Specialty

Oncology

DOI

10.7759/cureus.33309

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