Title
ALSUntangled #71: Nuedexta.
Document Type
Article
Publication Date
7-26-2023
Publication Title
Amyotroph Lateral Scler Frontotemporal Degener
Keywords
washington; spokane
Abstract
Nuedexta is a combination of dextromethorphan hydrobromide and quinidine sulfate and was approved by the Food and Drug Administration (FDA) in 2010 to treat pseudobulbar affect (PBA). There have since been anecdotal case reports of bulbar function improvements after Nuedexta treatment. Here, we review the off-label use of Nuedexta for improving bulbar function in people with ALS. Nuedexta has plausible mechanisms for protecting brain stem motor neurons via its effects on S1R and glutamate excitotoxicity. Recent clinical trials support that Nuedexta can improve bulbar function in PALS, with or without PBA. Nuedexta causes mild to moderate side effects. Based on this information, we support considering Nuedexta treatment for bulbar dysfunction in ALS patients with or without PBA.
Clinical Institute
Neurosciences (Brain & Spine)
Department
Neurosciences
Department
Pharmacy
Recommended Citation
Sun, Yuyao; Benatar, Michael; Mascías Cadavid, Javier; Ennist, Dave; Wicks, Paul; Staats, Kim; Beauchamp, Morgan; Jhooty, Sartaj; Pattee, Gary; Brown, Andrew; Bertorini, Tulio; Barkhaus, Paul; Bromberg, Mark; Carter, Greg; Bedlack, Richard; and Li, Xiaoyan, "ALSUntangled #71: Nuedexta." (2023). Articles, Abstracts, and Reports. 7676.
https://digitalcommons.providence.org/publications/7676