Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease.

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Publication Date


Publication Title

Hepatology (Baltimore, Md.)


Adult; Aged; Biopsy, Needle; Body Mass Index; Databases, Factual; Elasticity Imaging Techniques; Female; Humans; Immunohistochemistry; Logistic Models; Male; Middle Aged; Multivariate Analysis; Non-alcoholic Fatty Liver Disease; Obesity; Observer Variation; Retrospective Studies; Risk Assessment; Severity of Illness Index; Task Performance and Analysis; Vibration


Vibration-controlled transient elastography estimates liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), which are noninvasive assessments of hepatic fibrosis and steatosis, respectively. However, prior vibration-controlled transient elastography studies reported high failure rates in patients with nonalcoholic fatty liver disease. We examined the performance characteristics of the FibroScan 502 Touch with two probes, medium (M+) and extra large (XL+), in patients with nonalcoholic fatty liver disease in a multicenter setting. A total of 1,696 exams were attempted in 992 patients (body mass index, 33.6 ± 6.5 kg/m

CONCLUSION: Vibration-controlled transient elastography for estimation of LSM and CAP can be successfully deployed in a multicenter setting with low failure (3.2%) and high reliability (>95%) rates and high reproducibility. (Hepatology 2018;67:134-144).

Clinical Institute

Digestive Health