Complications from IV Alteplase in Mild Stroke Patients in a Multi-state Health System

Authors

• Lisa Yanase, Providence Brain and Spine Institute, Providence Health and Services, Portland, ORFollow
• Lindsay Lucas, Providence Brain and Spine Institute, Providence Health and Services, Portland, ORFollow
• Leslie Corless, Providence Brain and Spine Institute, Providence Health and Services, Portland, ORFollow
• Elizabeth Baraban, Providence Brain and Spine Institute, Providence Health and Services, Portland, ORFollow

Document Type

Presentation

Publication Date

2019

Keywords

oregon; providence neuroscience institute

Abstract

Risk of complication versus potential benefit is considered when deciding whether to treat acute ischemic stroke with IV alteplase (tPA). • Symptomatic intracerebral hemorrhage (sICH) rate is often quoted as 6.4% based on the NINDS trials. • sICH risk often makes patients and physicians wary of tPA treatment for mild ischemic stroke (MIS)1. • 2018 ASA guidelines removed MIS as a relative contraindication to tPA2. • A few small studies have revealed mixed outcomes and treatment complications in MIS2,3. • This study compared tPA-related complications in MIS vs. moderate-to-severe stroke in a large hospital system

Area of Special Interest

Neurosciences (Brain & Spine)

Specialty/Research Institute

Neurosciences