Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.
Publication Title
Carcinogenesis
Document Type
Article
Publication Date
3-8-2018
Keywords
Carcinoma, Non-Small-Cell Lung; Case-Control Studies; European Continental Ancestry Group; Gene-Environment Interaction; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Lung Neoplasms; Polymorphism, Single Nucleotide; Smoking
Abstract
Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never- versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13336 non-small cell lung cancer cases. Candidate SNPs with P-value
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
Specialty/Research Institute
Pulmonary Medicine
