Growth hormone-secreting pituitary macroadenoma presenting concurrently with non-Hodgkin's lymphoma and responding to doxorubicin treatment: case report and review of the literature.

Publication Title

Acta neurochirurgica

Authors

Gregory P Lekovic
Asheesh Batra
Zachary R Barnard
Eric P Wilkinson
Richard Balena, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA
Sheri Palejwala, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CAFollow
Garni Barkhoudarian, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CAFollow

Document Type

Article

Publication Date

12-1-2018

Keywords

Acromegaly; Doxorubicin; Non-Hodgkin’s lymphoma; Pituitary adenoma

Abstract

We present a case report of a patient who presented with nausea and vomiting, as well as acromegalic features. Following testing, a pituitary adenoma and mediastinal non-Hodgkin's lymphoma were diagnosed. Following two cycles of R-CHOP chemotherapy, imaging showed significant decrease in size of the sellar tumor. Following resection of tumor, both frozen and permanent section revealed only necrotic material. Further research into the potential utility of doxorubicin for the treatment of recurrent or refractory pituitary adenomas may be warranted.

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Specialty/Research Institute

Endocrinology