Document Type

Article

Publication Date

3-1-2018

Publication Title

Transplant international : official journal of the European Society for Organ Transplantation

Keywords

Biomarkers; Genome-Wide Association Study; Genomics; Heart Transplantation; Humans; Postoperative Complications; genes; genomics; histocompatibility and immunogenetics; immunobiology; molecular diagnostic; proteomics

Abstract

While advances in patient care and immunosuppressive pharmacotherapies have increased the lifespan of heart allograft recipients, there are still significant comorbidities post-transplantation and 5-year survival rates are still significant, at approximately 70%. The last decade has seen massive strides in genomics and other omics fields, including transcriptomics, with many of these advances now starting to impact heart transplant clinical care. This review summarizes a number of the key advances in genomics which are relevant for heart transplant outcomes, and we highlight the translational potential that such knowledge may bring to patient care within the next decade.

Clinical Institute

Cancer

Clinical Institute

Cardiovascular (Heart)

Department

Cardiology

Department

Oncology

Comments

Brian D. Piening is affiliated with Providence St. Joseph Health.

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