Confusing Blood Group Antibodies in Obstetrics: Focus on the Risk of Hemolytic Disease of the Fetus and Newborn.
Publication Title
American journal of perinatology
Document Type
Article
Publication Date
6-16-2025
Keywords
oregon; portland
Abstract
During routine prenatal antibody screening, maternal reactivity is sometimes detected for which the clinical significance is unclear. As a result, the strategy for monitoring these antibodies during pregnancy, to mitigate the risk of hemolytic disease of the fetus and newborn (HDFN), may be uncertain. This review focuses on four such immune responses in obstetrics: anti-G, anti-M, warm reactive autoantibodies, and apparent nonspecific immune responses that cannot be further classified. The relationship of these antibodies to HDFN is a primary focus. Related concerns, including maternal and neonatal transfusion considerations and candidacy for Rh immune globulin, are also addressed. · Pregnant patients with anti-G who lack anti-D are candidates for Rh immune globulin.. · Anti-M is a rare cause of HDFN.. · Warm reactive autoantibodies in pregnancy are unlikely to be clinically significant.. · Unless the patient is experiencing active hemolysis.. · Nonspecific reactivity is unlikely to be clinically significant in pregnancy.
Area of Special Interest
Women & Children
Specialty/Research Institute
Obstetrics & Gynecology
Specialty/Research Institute
Hematology
Specialty/Research Institute
Pathology & Laboratory Medicine
DOI
10.1055/a-2622-2841