Geno4ME Study: implementation of whole genome sequencing for population screening in a large healthcare system.
Publication Title
NPJ Genom Med
Authors
Isabelle Lucas-Beckett, Institute for Systems Biology, Seattle, WAFollow
Kate R Emery, Providence Health and Services, Renton, WA, USAFollow
Josiah T Wagner, Providence Health and Services, Renton, WA, USAFollow
Kathleen Jade, Institute for Systems Biology, Seattle, WA, USA.Follow
Benjamin Cosgrove, Providence Health and Services, Renton, WA, USAFollow
John Welle, Regional Pathology, Providence St. Joseph Health, Portland, Oregon, USAFollow
J B Rinaldi, Center for Outcomes Research and Education, Portland, OR, USA
Lindsay Dickey, Center for Outcomes Research and Education, Portland, OR, USAFollow
Kyle Jones, Center for Outcomes Research and Education, Portland, OR, USAFollow
Nick Wagner, Providence Health and Services, Renton, WA, USA.Follow
Eric Shull, Providence Health and Services, Renton, WA, USA.Follow
Jon Clemens, Providence Health and Services, Renton, WA, USA.Follow
Kalliopi Trachana, Institute for Systems Biology, Seattle, WAFollow
Lance Anderson, Providence Health and Services, Renton, WA, USA.Follow
Allison Kudla, Institute For Systems Biology, Seattle, WA, USA.Follow
Brett Smith, Institute for Systems BiologyFollow
Hakon Verespej, Institute For Systems Biology, Seattle, WA, USA.Follow
Li Chi Yuan, Providence Health and Services, Renton, WA, USA.Follow
Elizabeth Denne
Erica Ramos
Jennifer C Lovejoy, Institute For Systems Biology, Seattle, WA, USA.Follow
Krzysztof Olszewski
Martin G Reese
Misty J Reynolds, Providence Health and Services, Renton, WA, USA.Follow
Mandy M Miller, Providence Health and Services, Renton, WA, USA.Follow
Alexa K Dowdell, Providence Health and Services, Renton, WA, USA.Follow
Brianna Beck, Providence Health and Services, Renton, WA, USA.Follow
James Scanlan, Providence Health and Services, Renton, WA, USA.Follow
Mary B Campbell, Providence Health and Services, Renton, WA, USA.Follow
Andrew T Magis, Institute for Systems Biology, Seattle, WA, USAFollow
Keri B Vartanian, Center for Outcomes Research and Education, Portland, OR, USA.Follow
Brian D. Piening, Providence Health and Services, Renton, WA, USA.Follow
Carlo Bifulco, Providence Health and Services, Renton, WA, USA.Follow
Ora K Gordon
Publication Date
7-1-2025
Abstract
The Genomic Medicine for Everyone (Geno4ME) study was established across the seven-state Providence Health system to enable genomics research and genome-guided care across patients' lifetimes. We included multi-lingual outreach to underrepresented groups, a novel electronic informed consent and education platform, and whole genome sequencing with clinical return of results and electronic health record integration for 78 hereditary disease genes and four pharmacogenes. Whole genome sequences were banked for research and variant reanalysis. The program provided genetic counseling, pharmacist support, and guideline-based clinical recommendations for patients and their providers. Over 30,800 potential participants were initially contacted, with 2716 consenting and 2017 having results returned (47.5% racial and ethnic minority individuals). Overall, 432 (21.4%) had test results with one or more management recommendations related to hereditary disease(s) and/or pharmacogenomics. We propose Geno4ME as a framework to integrate population health genomics into routine healthcare.
Specialty/Research Institute
Center for Outcomes Research and Education (CORE)
