Cytokines Associated With Moderate and Severe Adverse Events During a Sporozoite Malaria Vaccine Trial with Controlled Human Malaria Infection.
Publication Title
The Journal of infectious diseases
Document Type
Article
Publication Date
8-14-2025
Keywords
IL-6; adverse events; controlled human infection model; controlled human malaria infection; cytokine; immune response; immunization; immunology; malaria; vaccine.; washington; isb
Abstract
Ensuring the safety and efficacy of candidate vaccines is critical. Although mechanisms underpinning protective immune responses to malaria vaccines are frequently investigated, immune responses correlating with moderate and severe adverse events are rarely examined. Here, we leverage a malaria vaccine trial with a higher-than-expected adverse event rate and frequent sampling to investigate cytokine profiles associated with adverse events. We found that Interleukin-6 was elevated on days in which individuals experienced moderate and severe adverse events. More research on immune responses associated with adverse events is warranted in order to identify biomarkers associated with systemic reactogenicity and accelerate vaccine development.
Specialty/Research Institute
Infectious Diseases
DOI
10.1093/infdis/jiaf435
