Genes associated with genetic and rare lung diseases and the risk of lung cancer.
Publication Title
Res Sq
Document Type
Article
Publication Date
8-11-2025
Keywords
CYP2A6; DMD; GARD; Hypothalamic-Pituitary-Adrenal axis; LTBP4; OMIM; Orphanet; adrenocorticotropic hormone; gene-based test; gene-set analysis; genomic marker; lung cancer; rare disease.; washington; swedish
Abstract
BACKGROUND: We investigated whether markers, genes or terms of the
METHODS: Genes of interest were extracted from
RESULTS: The marker rs56113850 (OR=0.893, 95%CI: 0.862-0.924) was associated with lung cancer (p=1.2×10
CONCLUSIONS: Genes associated with genetic and rare lung diseases do not generally appear to carry risk factors for lung cancer. However, genes associated with the hypothalamic-pituitary-adrenal axis show some, but rather weak or complex, associations with lung cancer. Tests at the gene level provide extremely inhomogeneous results, even when applied to the same data.
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
DOI
10.21203/rs.3.rs-7029929/v1
