Publication Title
Nat Commun
Document Type
Article
Publication Date
1-25-2019
Keywords
Breast Neoplasms; Case-Control Studies; Colorectal Neoplasms; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Head and Neck Neoplasms; Humans; Inheritance Patterns; Lung Neoplasms; Male; Mental Disorders; Neoplasm Proteins; Ovarian Neoplasms; Phenotype; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Smoking
Abstract
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
