Co-Var, a Measure to Determine Intra-protein, Inter-protein, Protein-DNA, or Protein-RNA Coevolution.
Publication Title
Methods in molecular biology (Clifton, N.J.)
Document Type
Article
Publication Date
1-1-2026
Keywords
washington; isb
Abstract
Interacting biomolecules tend to coevolve, and compensatory or coordinated residue changes may occur to preserve functional interactions. Predicting coevolutionary pairings could be important for determining structurally and functionally important residues in complexes or interfaces. Correlated variation (Co-Var) aims to determine both intramolecular and intermolecular coevolving residues in proteins, protein-protein, protein-DNA, or protein-RNA complexes. It utilizes two statistical parameters namely mutual information and Bhattacharyya coefficient. In this article, we have described how to utilize the Co-Var method to identify coevolutionary parings within and/or across biomolecules.
Specialty/Research Institute
Institute for Systems Biology
DOI
10.1007/978-1-0716-4828-5_5
