Endothelial cells as targets of immune checkpoint blockade.
Publication Title
J Immunother Cancer
Document Type
Article
Publication Date
11-16-2025
Keywords
Humans; Endothelial Cells; Immune Checkpoint Inhibitors; Neoplasms; Tumor Microenvironment; Immunotherapy; Animals; Immune Checkpoint Inhibitor; Immune modulatory.; oregon; chiles
Abstract
The tumor vasculature acts as the gatekeeper to the tumor microenvironment, thus regulating the ability of immune cells to roll, anchor, and cross the endothelium from blood to tissue. While the role of endothelial cells (EC) in T Cell migration and extravasation has been extensively studied, the ability of ECs to control T Cell function is less well appreciated. Several well-characterized regulators of T Cell function are expressed by ECs, while others are induced by soluble factors required for EC development and differentiation. Targeting the molecules expressed by immunomodulatory ECs may provide approaches to improve tumor immunotherapy.
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
DOI
10.1136/jitc-2025-013144
