Efficacy of Endoscopic Full Thickness Resection Using the Full-Thickness Resection Device for Submucosal Invasive Colorectal Cancer: The First United States Multicenter Experience.
Publication Title
Digestive diseases and sciences
Document Type
Article
Publication Date
10-27-2025
Keywords
washington; swedish; swedish dhi
Abstract
PURPOSE: Endoscopic full-thickness resection (EFTR) using full thickness resection device is used for removal of non-lifting or previously manipulated polyps. There is limited data regarding its efficacy for removal of colorectal submucosal invasive cancer (SMIC).
METHODS: We conducted retrospective multicenter study on patients who underwent EFTR using full thickness resection device for suspected or biopsy proven colorectal cancer (CRC).
RESULTS: Technical success was 100% and R0 resection rate was 85%. Overall, 6/20 were referred for surgery due to high risk features. Curative resection rate was 46.7% (7/15) in T1 CRC. Adverse events included 1 bleeding and 1 perforation, managed endoscopically and 1 bleeding and 2 post-polypectomy syndromes managed conservatively.
CONCLUSIONS: Our series provides the first multicenter experience on EFTR for resection of colorectal SMIC from the United States. Longitudinal data from large scale studies are required to validate our initial experience of EFTR for SMIC.
Area of Special Interest
Digestive Health
Area of Special Interest
Cancer
Specialty/Research Institute
Gastroenterology
Specialty/Research Institute
Oncology
Specialty/Research Institute
Swedish Digestive Health Institute
DOI
10.1007/s10620-025-09502-0
