Pregnancy, cancer, and radiation-a modern refresher.
Publication Title
JNCI Cancer Spectr
Document Type
Article
Publication Date
1-28-2026
Keywords
washington; swedish; swedish cancer
Abstract
PURPOSE: Cancer occurs in ∼1 per 1,000 pregnancies; thousands of patients may require radiation procedures for diagnosis and treatment each year. This rare but high-risk scenario, coupled with fear of radiation, has created ambiguity in the ideal management of pregnant patients. Without a comprehensive guide for the use of radiation in imaging and treatment for pregnant cancer patients, it is difficult for providers to provide optimal patient-centered care without introducing disparities. The goal of this paper is to provide guidance on the use of radiation for screening, diagnosis, staging, and treatment of cancer, while highlighting gaps in existing knowledge and guidelines. The intention is that physicians, medical physicists, and patients could use this document as a resource for shared decision-making, ensuring safe and effective practice.
METHODS AND MATERIALS: A team of physicians and medical physicists with expertise in imaging, radiotherapy, and maternal fetal medicine was assembled, along with a patient advocate and lawyer. Existing guidelines and recent literature were reviewed. Authors also drew from their experience where published guidance was lacking.
RESULTS: The resulting document discusses best practice to guide use of radiation for cancer, as well as patient-centered care management and legal considerations.
CONCLUSIONS: It is possible to safely and effectively deliver radiation to pregnant patients in numerous circumstances. Use of radiation or other modalities should be discussed through shared decision-making with the physician and patient, contextualizing the maternal and fetal risk from treatments. Healthcare providers should support wide access to reproductive healthcare to allow equitable, evidence-based, patient-centered healthcare.
Area of Special Interest
Cancer
Area of Special Interest
Women & Children
Specialty/Research Institute
Obstetrics & Gynecology
Specialty/Research Institute
Oncology
DOI
10.1093/jncics/pkag007
