Margin Analysis: Squamous Cell Carcinoma of the Oropharynx.

Publication Title

Oral Maxillofac Surg Clin North Am

Authors

Felix W Sim, Head and Neck Institute, Providence Cancer Center, Providence Portland Medical Center, 4805 Northeast Glisan Street, Suite 6N50, Portland, OR 97213, USAFollow
Hong D Xiao, Head and Neck Pathologist, Department of Pathology, Providence Portland Medical Center, 4805 Northeast Glisan Street, Suite 6N50, Portland, OR 97213, USAFollow
R Bryan Bell, Head and Neck Institute, Providence Cancer Center, Providence Portland Medical Center, 4805 Northeast Glisan Street, Suite 6N50, Portland, OR 97213, USAFollow

Document Type

Article

Publication Date

8-1-2017

Keywords

Carcinoma, Squamous Cell; Humans; Margins of Excision; Oropharyngeal Neoplasms; Papillomaviridae; Papillomavirus Infections

Abstract

Because of the common shared risk factors of smoking and heavy alcohol consumption, literature involving oropharyngeal squamous cell carcinoma (OPSCC) is often combined with oral squamous cell carcinoma. Human papilloma virus is now confirmed to be a major risk factor of OPSCC with its distinct epidemiology and favorable treatment outcome. The impact of adjuvant chemoradiation in the setting of positive surgical margins remains unclear but is likely influenced by tumor biology. This article reviews the tumor biology of OPSCC and summarizes recent findings on outcomes following surgical treatment of OPSCC.

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Specialty/Research Institute

Surgery