Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide-Embedded Large-Pore Mesoporous Organosilica Core-Shell Nanospheres.

Publication Title

Adv Healthc Mater

Authors

Lin Chen
Xiaobo Ma
Meng Dang
Heng Dong
Hong-Ming Hu, Laboratory of Cancer Immunobiology, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, USA.Follow
Xiaodan Su
Wenfei Liu
Qing Wang
Yongbin Mou
Zhaogang Teng

Document Type

Article

Publication Date

3-6-2019

Keywords

T cell activation; cancer immunotherapy; iron oxide; macrophage polarization; mesoporous organosilica

Abstract

Nanomaterial-based immunotherapy stimulating T cell activation or tumor-associated macrophage (TAM) conversion holds great promise for promoting tumor suppression. Herein, a novel nanoplatform, iron oxide-embedded large-pore mesoporous organosilica nanospheres (IO-LPMONs), is prepared for the first time to simultaneously activate cytotoxic T cells and polarize macrophages for potent tumor immunotherapy. The IO-LPMONs have large mesopores (6.3 nm) and inorganic-organic hybrid shells, which contribute to a high payload (500 µg mg

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Specialty/Research Institute

Earle A. Chiles Research Institute