Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway.

Publication Title

Front Pharmacol

Authors

Phuong Doan
Aliyu Musa
Nuno R Candeias
Frank Emmert-Streib
Olli Yli-Harja, Institute for Systems Biology, Seattle, WA, United States
Meenakshisundaram Kandhavelu

Document Type

Article

Publication Date

1-1-2019

Keywords

anticancer; apoptosis induction; cell cycle; cytotoxicity; gene expression; phenol

Abstract

Glioblastoma (GBM) is the most common type of malignant brain tumor in adults. We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human glioblastoma cell death. Its mechanism of action and the interaction of selective signaling pathways remain elusive. Three structurally related phenolic compounds were tested in multiple glioma cell lines in which the potential activity of the compound, THTMP, was further validated and characterized. Upon prolonged exposer to THTMP, all glioma cell lines undergo p53 and cyclin-dependent kinase mediated cell death with the IC

Clinical Institute

Cancer

Specialty/Research Institute

Oncology

Specialty/Research Institute

Institute for Systems Biology