anticancer; apoptosis induction; cell cycle; cytotoxicity; gene expression; phenol
Glioblastoma (GBM) is the most common type of malignant brain tumor in adults. We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human glioblastoma cell death. Its mechanism of action and the interaction of selective signaling pathways remain elusive. Three structurally related phenolic compounds were tested in multiple glioma cell lines in which the potential activity of the compound, THTMP, was further validated and characterized. Upon prolonged exposer to THTMP, all glioma cell lines undergo p53 and cyclin-dependent kinase mediated cell death with the IC
Institute for Systems Biology
Doan, Phuong; Musa, Aliyu; Candeias, Nuno R; Emmert-Streib, Frank; Yli-Harja, Olli; and Kandhavelu, Meenakshisundaram, "Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway." (2019). Articles, Abstracts, and Reports. 1411.