Publication Title
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
Document Type
Article
Publication Date
11-1-2017
Keywords
Adult; Continuous Positive Airway Pressure; Depression; Disorders of Excessive Somnolence; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Prospective Studies; Severity of Illness Index; Sleep Apnea, Obstructive; Time Factors; Wakefulness
Abstract
We evaluated factors associated with subjective and objective sleepiness at baseline and after 6 months of continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnoea (OSA).We analysed data from the Apnoea Positive Pressure Long-term Efficacy Study (APPLES), a prospective 6-month multicentre randomised controlled trial with 1105 subjects with OSA, 558 of who were randomised to active CPAP. Epworth sleepiness scale (ESS) scores and the mean sleep latency (MSL) on the maintenance of wakefulness test at baseline and after 6 months of CPAP therapy were recorded.Excessive sleepiness (ESS score >10) was present in 543 (49.1%) participants. Younger age, presence of depression and higher apnoea-hypopnoea index were all associated with higher ESS scores and lower MSL. Randomisation to the CPAP group was associated with lower odds of sleepiness at 6 months. The prevalence of sleepiness was significantly lower in those using CPAP >4 h·night
Specialty/Research Institute
Sleep Medicine
Specialty/Research Institute
Pulmonary Medicine
