Progress and Future Direction of Chromosome-Centric Human Proteome Project.
Publication Title
Journal of proteome research
Document Type
Article
Publication Date
12-1-2017
Keywords
Chromosomes, Human; Humans; Proteome; Research
Abstract
This special issue of JPR celebrates the fifth anniversary of the Chromosome-Centric Human Proteome Project (C-HPP). We present 27 manuscripts in four categories: (i) Metrics of Progress and Resources, (ii) Missing Protein Detection and Validation, (iii) Analytical Methods and Quality Assessment, and (iv) Protein Functions and Disease. We briefly introduce key messages from each paper, mostly from C-HPP teams and some from the Biology and Disease-driven HPP. From the first few months of the C-HPP NeXt-MP50 Missing Proteins Challenge, authors report 73 missing protein detections that meet the HPP guidelines using several novel approaches. Finally, we discuss future directions.
Specialty/Research Institute
Institute for Systems Biology
