Publication Title
Cureus
Document Type
Article
Publication Date
4-4-2017
Keywords
chordoma; development; embryology; notochord; nucleus pulposus; spine
Abstract
The notochord is a rod-like embryological structure, which plays a vital role in the development of the vertebrate. Though embryological, remnants of this structure have been observed in the nucleus pulposus of the intervertebral discs of normal adults. Pathologically, these remnants can give rise to slow-growing and recurrent notochord-derived tumors called chordomas. Using standard search engines, the literature was reviewed regarding the anatomy, embryology, molecular development, and pathology of the human notochord. Clinicians who interpret imaging or treat patients with pathologies linked to the notochord should have a good working knowledge of its development and pathology.
Clinical Institute
Neurosciences (Brain & Spine)
Specialty/Research Institute
Neurosciences
