Understanding the association between skin involvement and joint activity in patients with psoriatic arthritis: experience from the Corrona Registry.

Publication Title

RMD Open

Authors

Philip Mease, Swedish Rheumatology Research Group, Swedish Medical Center and University of Washington, Seattle, Washington, USAFollow
Carol J Etzel
William J Huster
Talia M Muram
April W Armstrong
Jeffrey R Lisse
Sabrina Rebello
Rhiannon Dodge
Mwangi James Murage
Jeffrey D Greenberg
William N Malatestinic

Document Type

Article

Publication Date

1-1-2019

Keywords

disease activity; outcomes research; psoriatic arthritis

Abstract

Objective: To compare the characteristics of patients with psoriatic arthritis among patient groups stratified by degree of skin and joint involvement, and to evaluate the relationship between skin severity and joint activity.

Methods: Body surface area (BSA) and Clinical Disease Activity Index (CDAI) at enrolment were analysed. Patient characteristics were stratified by skin severity and joint activity. Baseline patient characteristics, clinical and disease characteristics and patient-reported outcomes were compared. The strength of the relationship of skin severity and joint activity was evaluated using methods for categorical variables (χ

Results: 1542 adult patients in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry enrolled between 21 May 2013 and 20 September 2016 were analysed. Most patients in the BSA >3%/CDAI moderate/high subgroup had worse clinical and patient-reported outcomes. A significant (p

Conclusion: Skin severity is modestly correlated with joint activity, and patients with higher skin severity are two times more likely to have increased joint involvement. Clinicians need to address both skin severity and joint activity in treatment decisions.

Clinical Institute

Orthopedics & Sports Medicine

Specialty/Research Institute

Rheumatology

Specialty/Research Institute

Orthopedics