Early Identification of Intracranial Hemorrhage Using a Predictive Nomogram
Publication Title
Oncology nursing forum
Document Type
Article
Publication Date
3-1-2018
Keywords
Adult; Aged; Aged, 80 and over; Case-Control Studies; Early Detection of Cancer; Female; Hematologic Neoplasms; Humans; Intracranial Hemorrhages; Male; Maryland; Middle Aged; Neoplasm Staging; Nomograms; Predictive Value of Tests; Retrospective Studies
Abstract
OBJECTIVES: To identify predictive signs and symptoms occurring in hospitalized adults with hematologic malignancies with intracranial hemorrhage (IH). .
SAMPLE & SETTING: In a National Cancer Institute (NCI)-designated comprehensive cancer center, a retrospective matched case-control design included adult inpatients with hematologic malignancies with (n = 39) and without (n = 39) IH. .
METHODS & VARIABLES: Conditional logistic regression, t test, and Fisher's exact tests were used to assess increased risks for IH and the development of a prognostic nomogram with signs, symptoms, and laboratory values relevant to IH. .
RESULTS: Composite outcomes for signs, symptoms, and laboratory values were included in a prognostic nomogram that had good discriminative ability to predict IH, with a bootstrap corrected concordance index of 0.766 (95% confidence interval [0.657, 0.866]) and good calibration. Prognostic nomogram predicted patients with prolonged activated partial thromboplastin time (APTT) (greater than 30.6), headache, and systolic blood pressure (SBP) of 140 or greater were more likely to have IH. .
IMPLICATIONS FOR NURSING: Nurses should recognize that patients with the combination of prolonged APTT, SBP of 140 or greater, and headache are more likely to have IH.
Area of Special Interest
Cancer
Specialty/Research Institute
Oncology
Specialty/Research Institute
Nursing
