Publication Title
American journal of physiology. Gastrointestinal and liver physiology
Document Type
Article
Publication Date
7-1-2018
Keywords
Animals; Apoptosis; Central Nervous System Depressants; Complement Factor D; Complement Pathway, Alternative; Cytokines; Ethanol; Inflammation; Liver; Liver Diseases, Alcoholic; Mice; Mice, Inbred C57BL; Protective Agents
Abstract
Complement plays a crucial role in microbial defense and clearance of apoptotic cells. Emerging evidence suggests complement is an important contributor to alcoholic liver disease. While complement component 1, Q subcomponent (C1q)-dependent complement activation contributes to ethanol-induced liver injury, the role of the alternative pathway in ethanol-induced injury is unknown. Activation of complement via the classical and alternative pathways was detected in alcoholic hepatitis patients. Female C57BL/6J [wild type (WT)], C1q-deficient ( C1qa
Clinical Institute
Digestive Health
Specialty/Research Institute
Gastroenterology
Specialty/Research Institute
Hepatology
