American journal of physiology. Gastrointestinal and liver physiology
Animals; Apoptosis; Central Nervous System Depressants; Complement Factor D; Complement Pathway, Alternative; Cytokines; Ethanol; Inflammation; Liver; Liver Diseases, Alcoholic; Mice; Mice, Inbred C57BL; Protective Agents
Complement plays a crucial role in microbial defense and clearance of apoptotic cells. Emerging evidence suggests complement is an important contributor to alcoholic liver disease. While complement component 1, Q subcomponent (C1q)-dependent complement activation contributes to ethanol-induced liver injury, the role of the alternative pathway in ethanol-induced injury is unknown. Activation of complement via the classical and alternative pathways was detected in alcoholic hepatitis patients. Female C57BL/6J [wild type (WT)], C1q-deficient ( C1qa
McCullough, Rebecca L; McMullen, Megan R; Sheehan, Megan M; Poulsen, Kyle L; Roychowdhury, Sanjoy; Chiang, Dian J; Pritchard, Michele T; Caballeria, Juan; and Nagy, Laura E, "Complement Factor D protects mice from ethanol-induced inflammation and liver injury." (2018). Articles, Abstracts, and Reports. 1910.